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The Nobel Prize in Physiology or Medicine 2020 "for the discovery of Hepatitis C virus".


Entry details : D86529


GENERAL INFORMATION
ID D86529; SV 1; linear; genomic RNA; STD; VRL; 1158 BP.
Primary AC D86529
Creation Date 08-SEP-1998 (Rel. 56, Created)
Update Date 23-JAN-2011 (Rel. 122, Last updated , Version 0)
Description Hepatitis C virus partial genome, no 5'UTR, partial CDS (Contains: NS5B), partial 3'UTR.
Genotype
Deposited n.a.
Provisional 2q
Confirmed n.a.
Isolate BA045
Keywords partial genome;  partial CDS;  NS5B;  partial 3'UTR; 
Organism
OS Hepatitis C virus
OC Viruses;  ssRNA positive-strand viruses, no DNA stage;  Flaviviridae;  Hepacivirus; 
REFERENCES
[1]
1 - 1158
RA Okamoto H.; 
RL Submitted (15-JUL-1996) to the EMBL/GenBank/DDBJ databases. Hiroaki Okamoto, Jichi Medical School, Immunology Division; Yakushiji 3311-1, Minamikawachi-machi, Kawachi-gun, Tochigi 329-0498, Japan (E-mail: immundiv@jichi.ac.jp, Tel:81-285-58-7404, Fax:81-285-44-1557)
[2]
RA Tokita H.;  Okamoto H.;  Iizuka H.;  Kishimoto J.;  Tsuda F.;  Miyakawa Y.;  Mayumi M.; 
RT The entire nucleotide sequences of three hepatitis C virus isolates in genetic groups 7-9 and comparison with those in the other eight genetic groups
RL J. Gen. Virol. 79:1847-1857(1998).
FEATURES
source
1..1158
(1158)
db_xref taxon : 11103
db_xref EMBL : D86529
db_xref euHCVdb : AB031663
mol_type genomic RNA
organism Hepatitis C virus
misc_feature
<1..334
(334)
note NS5B genotyping region
gene
<1..1096
(1096)
locus_tag HCVORF1
CDS
<1..1096
(1096)
codon_start offset : 2
db_xref UniProtKB/TrEMBL : O92534
locus_tag HCVORF1
product Partial HCV polyprotein (contains NS5B).
translation VIEW
mat_peptide
<1..1093
(1093)

NS5B
function NS5B protein coding sequence (ns5b sequence)
locus_tag HCVORF1
product NS5B protein. Produced by proteolytic processing by the HCV NS3 protease. NS5B is a RNA-dependent RNA polymerase that plays an essential role in virus replication
prod_ft
chain 1..364  (364) RNA-dependent RNA polymerase (NS5B protein) (P68)
standard_name NS5B
3'UTR
1097..1158
(62)

3UTR
function 3'UTR (contains a polypyrimidine stretch and the conserved X region)
standard_name 3UTR
SEQUENCES
Sequence VIEW
Translation(s)
locus_tag HCVORF1 VIEW

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