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Entry details : D37844

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GENERAL INFORMATION
ID D37844; SV 1; linear; mRNA; STD; VRL; 1580 BP.
Primary AC D37844
Creation Date 24-OCT-1995 (Rel. 45, Created)
Update Date 23-JAN-2011 (Rel. 122, Last updated , Version 0)
Description Hepatitis C virus partial genome, complete 5'UTR, partial CDS (Contains: C, E1, E2), no 3'UTR.
Genotype
Deposited n.a.
Provisional 6f
Confirmed n.a.
Isolate Th271
Keywords partial genome;  complete 5'UTR;  partial CDS;  C;  E1;  E2; 
Organism
OS Hepatitis C virus
OC Viruses;  ssRNA positive-strand viruses, no DNA stage;  Flaviviridae;  Hepacivirus; 
[General] [References] [Features] [Sequences] [Text Entry]    [LANL]
REFERENCES
[1]
1 - 1580
RA Okamoto H.; 
RL Submitted (02-AUG-1994) to the EMBL/GenBank/DDBJ databases. Hiroaki Okamoto, Jichi Medical School, Immunology Division; Minamikawachi-machi, Kawachi-gun, Tochigi 329-04, Japan (Tel: 0285-44-2111(ex.3334), Fax:0285-44-1557)
[2]
1 - 1580
RA Tokita H.;  Okamoto H.;  Luengrojanakul P.;  Vareesangthip K.;  Chainuvati T.;  Iizuka H.;  Tsuda F.;  Miyakawa Y.;  Mayumi M.; 
RT Hepatitis C virus variants from Thailand classifiable into five novel genotypes in the sixth (6b), seventh (7c,7d) and ninth (9b, 9c) major genetic groups
RL J. Gen. Virol. 76:2329-2335(1995).
RX PUBMED: 7561773  
[General] [References] [Features] [Sequences] [Text Entry]    [LANL]
FEATURES
source
 1..1580
(1580)
db_xref taxon : 11103
db_xref EMBL : D37844
db_xref euHCVdb : DQ835760
mol_type mRNA
organism Hepatitis C virus
5'UTR
 1..338
(338)

5UTR
function 5'UTR highly conserved genomic region (contains four structural domains (I to IV), domains II to IV make up the internal ribosome entry site (IRES))
standard_name 5UTR
RBS
 41..351
(311)

IRES
function The internal ribosome entry site (IRES) is made up by domains II to IV of the 5'UTR
standard_name IRES
stem_loop
 5..18
(14)

5UTR-dI
function 5'UTR domain I has a regulatory effect for the replication and translation of the genome
standard_name 5UTR-dI
stem_loop
 41..115
(75)

5UTR-dII
function 5'UTR domain II is a component of the IRES
standard_name 5UTR-dII
stem_loop
 122..320
(199)

5UTR-dIII
function 5'UTR domain III is a component of the IRES
standard_name 5UTR-dIII
stem_loop
 328..351
(24)

5UTR-dIV
function 5'UTR domain IV is a component of the IRES
standard_name 5UTR-dIV
misc_feature
 866..1289
(424)

5UTR-dIV
note C/E1 genotyping region
gene
 339..>1580
(1242)

5UTR-dIV
locus_tag HCVORF1
CDS
 339..>1580
(1242)

5UTR-dIV
codon_start offset : 1
db_xref UniProtKB/TrEMBL : Q81269
locus_tag HCVORF1
product Partial HCV polyprotein (contains C, E1, E2).
translation VIEW
mat_peptide
 339..911
(573)

C
function C protein coding sequence (c sequence)
locus_tag HCVORF1
product RNA binding nucleocapsid protein (p21) (capsid) (core protein) (nucleocapsid) (C protein). Produced by proteolytic processing by the host signal peptidases
prod_ft
chain 1..191  (191) C protein
prod_ft
init_met 1..1  (1) Removed from C protein by the cellular aminopeptidase
standard_name C
mat_peptide
 912..1487
(576)

E1
function E1 protein coding sequence (e1 sequence)
locus_tag HCVORF1
product Envelope glycoprotein 1 (gp31) (E1 protein). Produced by proteolytic processing by the host signal peptidases. E1 forms heterodimers with the viral E2 envelope glycoprotein
prod_ft
chain 192..383  (192) E1 protein
prod_ft
transmem 353..381  (29) Potential transmembrane region of E1
standard_name E1
mat_peptide
 1488..>1580
(93)

E2
function E2 protein coding sequence (e2 sequence)
locus_tag HCVORF1
product Envelope glycoprotein 2 (GP70) (E2 protein). Produced by proteolytic processing by the host signal peptidases. E2 forms heterodimers with the viral E1 envelope glycoprotein
prod_ft
chain 384..414  (31) E2 protein
prod_ft
site 384..409  (26) Hypervariable region 1 (HVR1)
standard_name E2
[General] [References] [Features] [Sequences] [Text Entry]    [LANL]
SEQUENCES
Sequence VIEW
Translation(s)
locus_tag HCVORF1 VIEW
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