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Entry details : D37843


GENERAL INFORMATION
ID D37843; SV 1; linear; mRNA; STD; VRL; 1582 BP.
Primary AC D37843
Creation Date 24-OCT-1995 (Rel. 45, Created)
Update Date 23-JAN-2011 (Rel. 122, Last updated , Version 0)
Description Hepatitis C virus partial genome, complete 5'UTR, partial CDS (Contains: C, E1, E2), no 3'UTR.
Genotype
Deposited n.a.
Provisional 6c
Confirmed n.a.
Isolate Th846
Keywords partial genome;  complete 5'UTR;  partial CDS;  C;  E1;  E2; 
Organism
OS Hepatitis C virus
OC Viruses;  ssRNA positive-strand viruses, no DNA stage;  Flaviviridae;  Hepacivirus; 
REFERENCES
[1]
1 - 1582
RA Okamoto H.; 
RL Submitted (02-AUG-1994) to the EMBL/GenBank/DDBJ databases. Hiroaki Okamoto, Jichi Medical School, Immunology Division; Minamikawachi-machi, Kawachi-gun, Tochigi 329-04, Japan (Tel: 0285-44-2111(ex.3334), Fax:0285-44-1557)
[2]
1 - 1582
RA Tokita H.;  Okamoto H.;  Luengrojanakul P.;  Vareesangthip K.;  Chainuvati T.;  Iizuka H.;  Tsuda F.;  Miyakawa Y.;  Mayumi M.; 
RT Hepatitis C virus variants from Thailand classifiable into five novel genotypes in the sixth (6b), seventh (7c,7d) and ninth (9b, 9c) major genetic groups
RL J. Gen. Virol. 76:2329-2335(1995).
RX PUBMED: 7561773  
FEATURES
source
1..1582
(1582)
db_xref taxon : 11103
db_xref EMBL : D37843
db_xref euHCVdb : EF424629
mol_type mRNA
organism Hepatitis C virus
5'UTR
1..340
(340)

5UTR
function 5'UTR highly conserved genomic region (contains four structural domains (I to IV), domains II to IV make up the internal ribosome entry site (IRES))
standard_name 5UTR
RBS
42..353
(312)

IRES
function The internal ribosome entry site (IRES) is made up by domains II to IV of the 5'UTR
standard_name IRES
stem_loop
5..19
(15)

5UTR-dI
function 5'UTR domain I has a regulatory effect for the replication and translation of the genome
standard_name 5UTR-dI
stem_loop
42..116
(75)

5UTR-dII
function 5'UTR domain II is a component of the IRES
standard_name 5UTR-dII
stem_loop
123..322
(200)

5UTR-dIII
function 5'UTR domain III is a component of the IRES
standard_name 5UTR-dIII
stem_loop
330..353
(24)

5UTR-dIV
function 5'UTR domain IV is a component of the IRES
standard_name 5UTR-dIV
misc_feature
868..1291
(424)

5UTR-dIV
note C/E1 genotyping region
gene
341..>1582
(1242)

5UTR-dIV
locus_tag HCVORF1
CDS
341..>1582
(1242)

5UTR-dIV
codon_start offset : 1
db_xref UniProtKB/TrEMBL : Q81268
locus_tag HCVORF1
product Partial HCV polyprotein (contains C, E1, E2).
translation VIEW
mat_peptide
341..913
(573)

C
function C protein coding sequence (c sequence)
locus_tag HCVORF1
product RNA binding nucleocapsid protein (p21) (capsid) (core protein) (nucleocapsid) (C protein). Produced by proteolytic processing by the host signal peptidases
prod_ft
chain 1..191  (191) C protein
prod_ft
init_met 1..1  (1) Removed from C protein by the cellular aminopeptidase
standard_name C
mat_peptide
914..1489
(576)

E1
function E1 protein coding sequence (e1 sequence)
locus_tag HCVORF1
product Envelope glycoprotein 1 (gp31) (E1 protein). Produced by proteolytic processing by the host signal peptidases. E1 forms heterodimers with the viral E2 envelope glycoprotein
prod_ft
chain 192..383  (192) E1 protein
prod_ft
transmem 353..381  (29) Potential transmembrane region of E1
standard_name E1
mat_peptide
1490..>1582
(93)

E2
function E2 protein coding sequence (e2 sequence)
locus_tag HCVORF1
product Envelope glycoprotein 2 (GP70) (E2 protein). Produced by proteolytic processing by the host signal peptidases. E2 forms heterodimers with the viral E1 envelope glycoprotein
prod_ft
chain 384..414  (31) E2 protein
prod_ft
site 384..409  (26) Hypervariable region 1 (HVR1)
standard_name E2
SEQUENCES
Sequence VIEW
Translation(s)
locus_tag HCVORF1 VIEW

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