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The Nobel Prize in Physiology or Medicine 2020 "for the discovery of Hepatitis C virus".


Entry details : AY948146


GENERAL INFORMATION
ID AY948146; SV 1; linear; genomic RNA; STD; VRL; 456 BP.
Primary AC AY948146
Creation Date 01-SEP-2005 (Rel. 85, Created)
Update Date 23-JAN-2011 (Rel. 122, Last updated , Version 0)
Description Hepatitis C virus partial genome, no 5'UTR, partial CDS (Contains: NS5B), no 3'UTR.
Genotype
Deposited 1a
Provisional n.a.
Confirmed n.a.
Isolate A86-3018
Keywords partial genome;  partial CDS;  NS5B; 
Organism
OS Hepatitis C virus
OC Viruses;  ssRNA positive-strand viruses, no DNA stage;  Flaviviridae;  Hepacivirus; 
REFERENCES
[1]
1 - 456
RA van de Laar T.J.;  Langendam M.W.;  Bruisten S.M.;  Welp E.A.;  Verhaest I.;  van Ameijden E.J.;  Coutinho R.A.;  Prins M.; 
RT Changes in risk behavior and dynamics of hepatitis C virus infections among young drug users in Amsterdam, the Netherlands
RL J. Med. Virol. 77(4):509-518(2005).
RX DOI: 10.1002/jmv.20486  
PUBMED: 16254983  
[2]
1 - 456
RA van de Laar T.J.W.;  Langendam M.W.;  Bruisten S.M.;  Welp E.A.E.;  Verhaest I.;  van Ameijden E.J.C.;  Coutinho R.A.;  Prins M.; 
RL Submitted (28-FEB-2005) to the EMBL/GenBank/DDBJ databases. Infectious Diseases, Municipal Health Service, Nieuwe Achtergracht 100, Amsterdam 1018 WT, The Netherlands
FEATURES
source
1..456
(456)
country country : Netherlands
sub-region : Amsterdam
db_xref taxon : 11103
db_xref EMBL : AY948146
db_xref euHCVdb : M67463
mol_type genomic RNA
note genotype: 1a
organism Hepatitis C virus
misc_feature
<1..78
(78)
note NS5B genotyping region
gene
<1..>456
(456)
locus_tag HCVORF1
CDS
<1..>456
(456)
codon_start offset : 1
db_xref UniProtKB/TrEMBL : Q3ZDW6
locus_tag HCVORF1
product Partial HCV polyprotein (contains NS5B).
translation VIEW
mat_peptide
<1..>456
(456)

NS5B
function NS5B protein coding sequence (ns5b sequence)
locus_tag HCVORF1
product NS5B protein. Produced by proteolytic processing by the HCV NS3 protease. NS5B is a RNA-dependent RNA polymerase that plays an essential role in virus replication
prod_ft
chain 1..152  (152) RNA-dependent RNA polymerase (NS5B protein) (P68)
standard_name NS5B
SEQUENCES
Sequence VIEW
Translation(s)
locus_tag HCVORF1 VIEW

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