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The Nobel Prize in Physiology or Medicine 2020 "for the discovery of Hepatitis C virus".


Entry details : AJ291282


GENERAL INFORMATION
ID AJ291282; SV 1; linear; genomic RNA; STD; VRL; 332 BP.
Primary AC AJ291282
Creation Date 21-NOV-2000 (Rel. 65, Created)
Update Date 23-JAN-2011 (Rel. 122, Last updated , Version 0)
Description Hepatitis C virus partial genome, no 5'UTR, partial CDS (Contains: NS5B), no 3'UTR.
Genotype
Deposited 4a
Provisional 4r
Confirmed n.a.
Isolate FrSSD120
Keywords partial genome;  partial CDS;  NS5B; 
Organism
OS Hepatitis C virus subtype 4a
OC Viruses;  ssRNA positive-strand viruses, no DNA stage;  Flaviviridae;  Hepacivirus; 
REFERENCES
[1]
1 - 332
RA Deny P.; 
RL Submitted (22-MAY-2000) to the EMBL/GenBank/DDBJ databases.
[2]
1 - 332
RA Morice Y.;  Roulot D.;  Grando V.;  Stirnemann J.;  Gault E.;  Jeantils V.;  Bentata M.;  Jarousse B.;  Lotholary O.;  Pallier C.;  Deny P.; 
RT Phylogenetic analyses confirm the high prevalence of hepatitis C virus (HCV) type 4 in the Seine-Saint-Denis district (France) and indicate seven different HCV-4 subtypes linked to two different epidemiological patterns
RL J. Gen. Virol. 82(Pt 5):1001-1012(2001).
RX PUBMED: 11297675  
FEATURES
source
1..332
(332)
country country : Democratic Republic of the Congo
sub-region :
db_xref taxon : 31653
db_xref EMBL : AJ291282
db_xref euHCVdb : FJ462439
mol_type genomic RNA
note type 4a (Z4 isolate-like)
organism Hepatitis C virus subtype 4a
misc_feature
<1..>332
(332)
note NS5B genotyping region
gene
<1..>332
(332)
locus_tag HCVORF1
CDS
<1..>332
(332)
codon_start offset : 2
db_xref UniProtKB/TrEMBL : Q9DWK0
locus_tag HCVORF1
product Partial HCV polyprotein (contains NS5B).
translation VIEW
mat_peptide
<1..>332
(332)

NS5B
function NS5B protein coding sequence (ns5b sequence)
locus_tag HCVORF1
product NS5B protein. Produced by proteolytic processing by the HCV NS3 protease. NS5B is a RNA-dependent RNA polymerase that plays an essential role in virus replication
prod_ft
chain 1..110  (110) RNA-dependent RNA polymerase (NS5B protein) (P68)
standard_name NS5B
SEQUENCES
Sequence VIEW
Translation(s)
locus_tag HCVORF1 VIEW

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